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ARV Function

ARV Function – Antiretrovirals (ARVs) act at the level of the enzyme reverse transcriptase, integrase and protease are at the core of HIV.

Currently, antiretroviral treatment includes a combination of three or four drugs of the same or different mechanism of action.

The most used are the reverse transcriptase inhibitors among which is the AZT (zidovudine), Videx (Didanosine), Epivir (lamivudine), Viramune (nevirapine), Stocrin (Efavirenz) among others.

Transcriptase Inhibitors
These are drugs that inhibit the action of HIV reverse transcriptase enzyme, ie above do not allow it to become viral RNA into DNA thus preventing HIV replication.

Other medications such as Inhibiting Protease
These are drugs that act at the end of the viral replication by inhibiting the function of the HIV protease enzyme, resulting in the HIV replication in defective versions unable to infect other cells. Among these are: Agenerase (amprenavir) and Kaletra (lopinavir plus ritonavir).

As of August 2005 in Honduras are about 3,200 people on ART according to the Ministry of Health of Honduras, who has the capacity to treat 4,000 people.

Why give antiretroviral therapy ARV commonly called?
Treatment should be given to avoid further multiplying or reproducing HIV, avoid the appearance of opportunistic infections, restore or preserve immune function.

These drugs have side effects that cause much discomfort who take them, sometimes causing the abandonment of treatment.

The person should remember that these side effects occur while your body adjusts to these medications and therefore should not abandon the drugs.

The most common complaints that can be felt when taking ARVs are:
* Nausea and vomiting
* Heartburn
* Insomnia and nightmares
* Diarrhea
* Headache